Vascular Diseases

Plexogenic angiopathy

In plexogenic angiopathy, the parent muscular artery shows medial and intimal thickening. The plexiform lesion develops at a branch point (arrow) probably as a result of shear stress. Damage results in transmural destruction that is repaired by granulation tissue (=plexiform lesion). An elastic tissue stain would show loss of one or both of the elastic layers.

Dilation lesion: This plexiform lesion (center) is surrounded by a number of dilated, empty vascular channels (arrows) of the post-plexiform dilation lesion.


Plexiform lesions are found in primary pulmonary hypertension, and certain types of congenital heart disease. They also occur in pulmonary hypertension of AIDS, schistosomiasis, cirrhosis of the liver, ingestion of certain diet pills, etc.