Large cell carcinoma

Tumor cells have abundant cytoplasm, clumped chromatin (blue), and pink nucleoli (arrow), but no evidence of gland formation, mucin production, bridges, or pearls. A giant cell variant occurs.


Adenocarcinomas show gland formation or neutral mucin production (PAS-D+). This tumor is composed of glands. The stroma has many inflammatory cells.

Bronchioloalveolar carcinoma

Columnar tumor cells line preformed alveolar walls and stimulate some production of fibrous tissue in the walls; solitary nodular types outnumber the multifocal diffuse types.

Contrast the enlarged, columnar tumor cells (lower right) with the normal, ciliated epithelium (upper left).