Overview of Pulmonary Pathology

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Yeast fungi

• Pneumocystis carinii, now P. jiroveci

Differential diagnosis of homogeneous pink material

• Pulmonary alveolar proteinosis, Amyloid, Protein-rich edema fluid, Inspissated mucus in alveoli in bronchioloalveolar cancer

More yeast fungi

• Cryptococcus neoformans, Coccidioides immitis
• Histoplasma capsulatum, Blastomyces dermatitidis

Hyphal fungi

• Aspergillus, Candida, Mucor

Toxoplasma

Virus and chlamydia/mycoplasma

• H. zoster-simplex , Adenovirus, Measles virus
• Cytomegalovirus, Respiratory syncytial virus
• Influenza--no inclusions
• Chlamydia--intracytoplasmic inclusion bodies, Giemsa positive; DFA on paraffin-embedded tissue
• Mycoplasma--no inclusions

Bacterial pneumonia

• Lobar, Lobular--Legionnaire's disease
• Bronchopneumonia, Necrotizing pneumonia
• Nocardia, Aspiration
• Tuberculosis
• Non-tuberculous mycobacterial disease, Bronchocentric granulomatosis

Lipoid pneumonia

• Exogenous, Endogenous

Tumors

• Large cell carcinoma, Adenocarcinoma, Bronchioloalveolar carcinoma
• Squamous carcinoma
• Carcinoid tumor, Atypical carcinoid tumor (well-differentiated neuroendocrine carcinoma), Small cell carcinoma
• Mucoepidermoid carcinoma, Adenoid cystic carcinoma
• Hamartoma, Papilloma
• Kaposi's sarcoma
• Diffuse malignant mesothelioma
• Metastatic tumor

Lymphoproliferative diseases

• Lymphocytic interstitial pneumonia, Low-grade, small cell lymphoma (Primary pulmonary lymphoma of BALT (B-cell type))
• Low-grade, small cell lymphoma, Angioimmunoproliferative lesion (Lymphomatoid granulomatosis)
• Large cell lymphoma
• Hodgkin's disease, Body-cavity-based lymphoma, Intravascular lymphoma

Airways disease

• Emphysema
• Chronic bronchitis, Small airways disease
• Bronchiectasis, Immotile (dyskinetic) cilia, Tracheobronchopathia osteochondroplastica
• Asthma
• Bronchiolitis

Interstitial pneumonias

• Usual interstitial pneumonia
• Desquamative interstitial pneumonia, Respiratory bronchiolitis
• Non-specific interstitial pneumonia, Rheumatoid nodule, Hypersensitivity pneumonia
• Sarcoidosis/Beryllium disease
• Giant cell interstitial pneumonia, Langerhans' cell histiocytosis
• Churg-Strauss syndrome, Eosinophilic pneumonia
• Wegener's granulomatosis
• Lymphangioleiomyomatosis

Drug toxicity

• Busulfan, Cyclophosphamide
• Bleomycin, Amiodarone

Pulmonary hemorrhage syndromes

• Diffuse alveolar hemorrhage, Goodpasture's, Lupus erythematosus

Pneumoconiosis

• Asbestosis, Pleural plaques, Round atelectasis
• Silicosis, Silico-proteinosis,Talc granulomas
• Crack black lung, Mixed dust pneumoconiosis

Vascular disease

• Plexogenic angiopathy
• Veno-occlusive disease, Thromboembolic disease, Arterio-venous malformation

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Last revised 5/2/06

Copyright 1999 Martha L. Warnock. All rights reserved.