Mycobacterial Diseases

Non-tuberculous mycobacterial pneumonia in AIDS

In AIDS, non-tuberculous mycobacteria produce interstitial collections of macrophages that have a striated appearance because they are filled with organisms. Granulomas are not usually present.

Non-tuberculous mycobacteria in AIDS--acid fast stain

An acid fast stain shows the large numbers of organisms that are present in each cell.

Bronchocentric granulomatosis

This bronchiole is almost completely occluded by granulomatous inflammation. Two small lumens remain (arrows). This lesion is frequent in non-tuberculous mycobacterial infections in the non-immunocompromised, where it may be associated with bronchiectasis.

Bronchocentric granulomatosis, a reaction pattern and not a disease, also occurs with tuberculosis, allergic bronchopulmonary aspergillosis, and other infectious and non-infectious conditions. It may be idiopathic.