Hodgkin's disease in the lung is usually secondary to disease elsewhere. It is characterized by the presence of Reed-Sternberg cells (CD15 and CD30-positive) and a mixed, reactive, inflammatory infiltrate of PMNs, eosinophils, and lymphoid cells.
Hodgkin's Disease, Body-Cavity-Based Lymphoma,
Intravascular Lymphoma
Hodgkin's disease
|
|
Hodgkin's disease in the lung is usually secondary to disease elsewhere. It is characterized by the presence of Reed-Sternberg cells (CD15 and CD30-positive) and a mixed, reactive, inflammatory infiltrate of PMNs, eosinophils, and lymphoid cells. | ||||||
Reed-Sternberg cell
|
|
R-S cells have bilobed or double nuclei with prominent nucleoli (arrow). Other types of malignant cells can mimic R-S cells, and thus, the reaction of these cells with CD15 and CD30 is helpful in confirming a diagnosis of Hodgkin's disease. Note the PMNs. Other cells with small nuclei are lymphocytes and plasma cells. | ||||||
Body-cavity-based lymphoma--pleural space
|
|
This lymphoma presents as a pleural effusion. Atypical lymphoid cells are larger than normal lymphocytes and have clumped, dark nuclear chromatin. Clonality for B cells can be demonstrated. This lymphoma is a Kaposi sarcoma herpesvirus (human herpesvirus-8)-related disease. | ||||||
Compare the size of the eosinophil and PMN (arrows) to that of the tumor cells.
Intravascular lymphoma
|
|
Rarely, large cell lymphomas, usually B-cell type, remain confined to blood vessels. They present with neurologic symptoms or dyspnea. This vessel shows many cells with large, pale, irregular nuclei. A few lymphocytes are also present (arrow). | ||||||
Intravascular lymphoma--B-cell stain
|
|
The neoplastic cells (CD20-positive) plug capillaries. This vascular obstruction produces the dyspnea. | ||||||
