Drug Toxicities

Bleomycin toxicity

Patterns include diffuse or nodular, organizing non-specific interstitial pneumonia. Here, an organizing, nodular interstitial pneumonia is present subpleurally.

Amiodarone toxicity

Amiodarone may produce a non-specific interstitial pneumonia with foamy alveolar macrophages filling air spaces.

Amiodarone effect in alveolar macrophage

Ultrastructurally, the foamy macrophages contain many lamellated bodies resembling surfactant (arrow indicates one).