The pattern is a non-specific interstitial pneumonia with scattered large atypical epithelial cells, which are shown below.
Drug Toxicities
Busulfan toxicity
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The pattern is a non-specific interstitial pneumonia with scattered large atypical epithelial cells, which are shown below. | ||||||
Busulfan toxicity
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Busulfan produces marked atypia of type II cells in the lung and glandular cells of other organs. Nuclei are hyperchromatic, and the N/C ratio is increased. Compare the size of the atypical cells (arrows) with adjacent type II cells. These cells should not be mistaken for CMV-infected cells, which have nuclear and cytoplasmic inclusions. | ||||||
Cyclophosphamide toxicity
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Cyclophosphamide toxicity shows a non-specific interstitial pneumonia with type II cell atypia, but less so than with busulfan. | ||||||
