Histologic Changes

Bronchioles have thick walls, chronic inflammatory cells, black pigment, and erosion of epithelium. Peribronchiolar, emphysematous spaces (E) (centriacinar emphysema) are surrounded by preserved alveoli.

A more pronounced lymphocytic bronchiolitis, which may represent a non-specific, interstitial pneumonia of HIV infection, is present around some airways. Lymphocytes and plasma cells compose the infiltrate that narrows and distorts branches (center) of the parent bronchiole to the left (B). There was no residue of the previous interstitial pneumonia in this biopsy.

Clinical summary Image 6

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