Diffuse Nodular Interstitial Amyloidosis

Radiology

Diffuse nodular interstitial amyloid deposition presents as a diffuse linear or nodular pattern, occasionally verging on frank consolidation when extensive and confluent. On HRCT, variably-sized perilymphatic nodules may be seen; the nodules may calcify or ossify. Thickened septa may be present, and ground-glass opacity may also be seen.

Figure 1--Chest Radiograph

This 55-year-old man had progressive dyspnea for which he received a lung transplant.

Figure 2--HRCT Soft Tissue Window

This post-transplant HRCT shows marked calcification of confluent nodules in the native lung. Mediastinal lymphadenopathy is also present.


Pathology

bone1bone2bone3amyloidmarrow

Figure 3

A calcified focus of this man's explanted lung shows amyloid, bone and marrow.

Find 3 examples of bone, one with cartilage. Note the osteocytes in the bone.

Find an area of amyloid.

Outline the bone marrow.

For more information on this particular patient, click here. For another example of diffuse nodular interstitial light chain deposition disease, click here.

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Bone with central blue cartilage

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Bone marrow

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