Further Histologic Features

Figure 1

Most of the tumor consisted of closely-packed, polygonal cells, some showing nuclear molding (indentation of one nucleus by another because of scant cytoplasm) as shown in the right half of the image. A few areas showed spindled cells (center), and other areas (left) had cells with more cytoplasm. Vessels are not prominent here.


Figure 2

In other areas, enlarged vessels lined only by endothelial cells were more prominent. Note that the tumor cells directly contact the endothelial cells.

Most tumor cells have rounded nuclei and finely-divided chromatin, but a few have prominent nucleoli.

Mitoses were present (14 per 50 high power fields). Necrosis was absent.

Find a mitotic figure.

What immunohistochemical tests might help in the diagnosis?


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Mitotic figure