Figure 1.
Most malignant SPNs primary in the lung are adenocarcinomas. The following images, in descending order of frequency [1], show examples of other primary lung malignancies presenting as SPNs. Give diagnosis, histologic criteria, and corroborative special stains for each tumor.
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Figure 1. | ||||||||||
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Figure 2. | ||||||||||
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Figure 3. | ||||||||||
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Figure 4. | ||||||||||
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Figure 5. | ||||||||||
Reference
Siegelman S, Khouri N, Leo F, Fishman E, Braverman R, Zerhouni E. Solitary pulmonary nodules: CT assessment. Radiology 1986:160:307-312. Abstract
Return to Pathologic Diagnoses
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1. Squamous Carcinoma Intercellular bridges (desmosomes) in left nest and a keratin pearl in right nest are present. | ||||||||||
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2. Large Cell Carcinoma Squamous or glandular differentiation is absent. Staining for neutral mucin (PAS-D) to indicate glandular differentiation was negative. | ||||||||||
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3. Bronchioloalveolar Carcinoma Tumor cells line alveolar walls. Note that the tumor cells here are larger and more hyperchromatic than the normal bronchiolar epithelium of the airway at the lower left. | ||||||||||
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4. Small Cell Carcinoma Hyperchromatic cells show nuclear molding because of very high nuclear-cytoplasmic (N/C) ratios, and nucleoli are generally absent. Mitotic rate is high. A stain for chromogranin A was positive indicating a neurosecretory cell type. | ||||||||||
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5. Carcinoid Tumor The tumor has a trabecular pattern of cells with low N/C ratios, finely granular chromatin (not well shown here), and rare mitotic figures. A stain for chromogranin A was positive indicating a neurosecretory cell type. | ||||||||||
