Histologic Changes of Postmortem Lung

A. At least one bronchiole in each section of lung showed partial obliteration of the lumen by granulation tissue (arrow). Some foreign vegetable matter was usually found embedded in the granulation tissue. The inset (stained with the GMS stain) shows the foreign material better.

B. Other small airways were plugged with organisms that stained with the silver stain (GMS). What are these organisms?

Answer

C. This structure (arrow) was found in the wall of a small airway (respiratory epithelium lies at the bottom right). What is the structure? What is its significance?

Answers

Clinical summary Discussion

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B

B. Other small airways were plugged with organisms that stained with the silver stain (GMS). What are these organisms? Aspergillus. Note the acute angle branches and septa. The diameter is about that of a red blood cell, but unfortunately, none is present in the section.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

C

C. This structure (arrow) was found in the wall of a small airway (respiratory epithelium lies at the bottom right). What is the structure? A ferruginous body, a non-specific term for a mineral fiber that has been coated with an iron-protein coat in a macrophage (long since gone). This body with a thin, transparent core may represent an asbestos body in this man who probably had exposure to asbestos as a mechanic, but it could have another type of mineral core.

What is its significance? It signifies only past exposure to fibrous dust. In this man, the dose inhaled did not produce any dust-related disease.

Clinical summary Discussion

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