Answer: Image 1A: Is the inflammation temporally all of the same age, or are there recent and old components? In all areas of the biopsy, the inflammatory changes were of the same age. There was no evidence of old scar, which would be darker pink.

Where is the inflammation occurring? In alveolar spaces, or in the interstitium? The inflammation is both in the alveolar spaces and in the interstitium. In this entity, the interstitial component usually predominates. The alveolar component gradually becomes epthelialized and incorporated into the interstitium.

What type of tissue is present around the asterisks? Granulation tissue, which is a mixture of spindled, myofibroblastic, connective tissue cells, capillaries, and mostly chronic inflammatory cells.

Image 1C: What types of cells are causing the widening of the alveolar walls? Walls are widened by the granulation tissue and hyperplastic type II cells. The thickened alveolar walls and increased numbers of alveolar macrophages constitute an alveolitis, which is one component of interstitial pneumonia. Inflammation around airways and vessels is also present in interstitial pneumonia.

Image 1

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