Histologic changes: Most of the cells in the tumor resembled those to the right. These cells have a benign appearance: low N/C ratios and regular, rounded nuclei. Some areas in both the laryngeal and lung lesions showed the changes depicted in the left 80% of the photo. These cells are rounded, squamous cells with obscure cell boundaries, homogenous and condensed cytoplasm, and dark, angulated, sometimes enlarged nuclei with a sharply-demarcated paranuclear halo. The nucleus is usually located eccentrically in the halo (arrow indicates one). When these changes occur in the absence of inflammation, they are strongly suggestive of a viropathic effect. The term koilocytic, from koilos meaning hollow, is used to describe this change.

Case 8--Clinical SummaryImage 5

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