Interstitial Pneumonia

In another part of the biopsy, this pattern was present. What is it? What clinical symptoms and signs accompany this lesion? Answers

Three vessels are shown here. Are these arteries or veins? Are they normal? What type of inflammatory response is present? Answers

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Answers : What is this pattern? What clinical symptoms and signs accompany this lesion?

Non-specific interstitial pneumonia (cellular interstitial pneumonia): This pattern has a temporally uniform appearance: no old fibrosis or recent granulation tissue (fibroblastic foci) is present. Alveolar walls are widened by type II cells and a mild chronic inflammatory infiltrate. There are a few macrophages and inflammatory cells in the alveolar spaces.

Patients with this lesion may have dyspnea and cough. There may be restriction on PFTs along with hypoxemia that worsens with exercise. Ground-glass opacities may be seen on HRCT.

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Answers

 

Are these vessels arteries or veins? Small veins. There are no adjacent airways and the muscular media is very thin (seen especially well in the vessel at the lower right).

Are they normal? Their intimas are thickened, and the lumens are narrowed.

What type of inflammatory response is present? There is a lymphoid infiltrate in the thickened adventitia. This type of perivenous inflammation is common in immunologic lung diseases with an interstitial pneumonia.

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