Histologic Changes

At high magnification the nuclei are basally oriented and vesicular with small nucleoli and irregular shapes. Mitotic figures were infrequent. The apical cytoplasm is vacuolated, suggesting mucus production. A PAS-D stain for mucin was positive in the cytoplasmic vacuoles.

An artery (A) has two gland-like structures within its adventitia (arrows). What do they represent? Answer

Clinical summary Discussion

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Answer: These gland-like structures represent tumor in lymphatics that run in the bronchovascular bundles (this instance), interlobular septa, and pleura. Lymphatics are a common means of spread of tumor.

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