Histologic Features

A

The edge of this nodule (lower right) shows tumor growing into a bronchiole lined by respiratory epithelium. At the lower left, tumor has undergone coagulation necrosis and is being organized by some new vessels (arrows) and connective tissue. Such necrotic tissue frequently undergoes dystrophic calcification (i.e., calcification in an area of necrosis). Note that the majority of the nodule is devoid of vessels.

B

In image B the central structure between the arrows has tumor in it. The structure can be identified by recognizing the type of cells the arrows touch. What type of cells are these? What structure is being invaded? What special stain might help to confirm your diagnosis? Answers

Clinical summary Image 4

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Answers:

B

In image B the central structure between the arrows has tumor in it. The structure can be identified by recognizing the type of cells the arrows touch.

What type of cells are these? Smooth muscle cells with elongate nuclei

What structure is being invaded? A blood vessel

 

What special stain might help to confirm the diagnosis? An elastic tissue stain, such as elastic van Gieson. If an inner and outer elastic layer are present around the smooth muscle media, it is an artery. If a single elastic layer is present, it is a vein.

Clinical summary Image 4

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