Histologic Changes

Other areas of tumor show plump, spindled cells with pale nuclei and prominent nucleoli.

Histochemical stains for neutral mucin (PAS-D and mucicarmine) and immunohistochemical stains for B72.3, CD-15 (Leu-M1), and carcinoembryonic antigen (CEA) were negative. A stain for cytokeratin was positive. What is the diagnosis of this man's tumor? Answer

Clinical summary Discussion

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Answer: This tumor is a diffuse, malignant mesothelioma of the pleura. It is a biphasic tumor with epithelial and sarcomatous (spindled) components. The special stains for mucin, B72.3, CD15, and CEA, which would be positive with an adenocarcinoma, were all negative. The positive stain for cytokeratin does not distinguish a biphasic adenocarcinoma with glandular and spindled components from malignant mesothelioma.

Clinical summary Discussion

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