Histologic Changes

The photo shows a bronchiole with scattered peribronchiolar lymphoid cells that focally infiltrate the epithelium. These changes represent a lymphocytic bronchiolitis.

This section is stained immunohistochemically for T lymphocytes (CD3) to show the invasion of the epithelium by T cells. This invasion is associated with focal epithelial erosions.

This section is stained with an elastic-van Gieson stain that colors elastic tissue black and collagen red. A remnant of respiratory epithelium is present at the arrow, and an artery lies at the upper left. Faintly pink tissue fills the lumen of the airway and spreads to adjacent air spaces. What pattern of reaction is represented? Answer

Clinical summary Image 3

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Answer:

What pattern of reaction is represented? The light pink tissue in the airway lumen contains spindled myofibroblasts and represents granulation tissue. Its attachment to the airway wall and spread into adjacent air spaces represents a BOOP-like (or COP-like) pattern.

Clinical summary Image 3

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