Histologic changes: Several airways showed the changes seen below (A), but the process was patchy, and some airways were almost normal. Although cell type cannot be discerned at this magnification, what types of cells are likely present in the airway lumen, and what types invade the epithelium and peribronchiolar connective tissue? Answer

Note that the epithelium is taller than usual and that the inflammatory cells are causing epithelial destruction, especially between the arrows.

A

A smaller bronchiole (B) has similar changes with tall columnar epithelium infiltrated by the lymphocytes (small, dark nuclei) that surround it. Inflammation and fibrosis narrow the lumen producing a constrictive, lymphocytic bronchiolitis.

B

Case 10--Clinical summary Image 2

 

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